Cheap flights to Des Moines, Iowa (DSM)

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$263 RT
Atlanta, GA (ATL) No min. stay.. Late Summer/Fall travel; Nonstop flights. (Delta) See all details »
$360 RT
Atlanta, GA (ATL) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$359 RT
Austin, TX (AUS) Lowest fare found for travel within the next 30 days. (American) See all details »
$333 RT
Baltimore, MD (BWI) Lowest fare found for travel within the next 30 days. (United) See all details »
$380 RT
Boston, MA (BOS) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$410 RT
Burbank, CA (BUR) Lowest fare found for travel within the next 30 days. (United) See all details »
$310 RT
Charlotte, NC (CLT) Lowest fare found for travel within the next 30 days. (Delta) See all details »
$199 RT
Chicago, IL (ORD) Non-Stop Flights.. No min. stay.. No peak holiday travel at this price. (United, American) See all details »
$216 RT
Chicago, IL (MDW) No peak holiday travel at this price. (Delta) See all details »
$200 RT
Chicago, IL (MDW) No min. stay.. Fare can be bought one-way for half the lowest roundtrip... (Southwest) See all details »
$235 RT
Chicago, IL (ORD) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$258 RT
Chicago, IL (MDW) Lowest fare found for travel within the next 30 days. (Delta) See all details »
$168 RT
Chicago, IL (ORD) Nonstop; Travel this weekend. (United) See all details »
$344 RT
Cleveland, OH (CLE) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$369 RT
Columbus, OH (CMH) Lowest fare found for travel within the next 30 days. (American) See all details »
$228 RT
Dallas, TX (DFW) Lowest fare found for travel within the next 30 days. (American) See all details »
$361 RT
Dallas, TX (DAL) Lowest fare found for travel within the next 30 days. (Delta) See all details »
$194 RT
Denver, CO (DEN) Lowest fare found for travel within the next 30 days. (Frontier) See all details »
$105 RT
Denver, CO (DEN) Fall travel; Nonstop flights.. No min. stay.. Fare can be bought one-wa... (Frontier) See all details »
$339 RT
Detroit, MI (DTW) No min. stay.. Late Summer/Fall travel; Nonstop flights. (Delta) See all details »
$314 RT
Detroit, MI (DTW) Lowest fare found for travel within the next 30 days. (United, US Airways, American) See all details »
$380 RT
Ft. Lauderdale, FL (FLL) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$397 RT
Ft. Myers, FL (RSW) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$324 RT
Grand Rapids, MI (GRR) Lowest fare found for travel within the next 30 days. (United) See all details »
$399 RT
Hartford, CT (BDL) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$408 RT
Houston, TX (IAH) Lowest fare found for travel within the next 30 days. (American) See all details »
$408 RT
Houston, TX (HOU) Lowest fare found for travel within the next 30 days. (American) See all details »
$346 RT
Indianapolis, IN (IND) Lowest fare found for travel within the next 30 days. (United, Delta, US Airways, American) See all details »
$425 RT
Jacksonville, FL (JAX) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$286 RT
Las Vegas, NV (LAS) No min. stay.. Fare can be bought one-way for half the lowest roundtrip... (Southwest) See all details »
$283 RT
Las Vegas, NV (LAS) Lowest fare found for travel within the next 30 days. (United) See all details »
$321 RT
Los Angeles, CA (LAX) Lowest fare found for travel within the next 30 days. (United) See all details »
$340 RT
Minneapolis, MN (MSP) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$318 RT
Nashville, TN (BNA) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$365 RT
New Orleans, LA (MSY) Lowest fare found for travel within the next 30 days. (United) See all details »
$381 RT
New York City, NY (JFK) Lowest fare found for travel within the next 30 days. (American) See all details »
$382 RT
New York City, NY (LGA) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$392 RT
Newark, NJ (EWR) Lowest fare found for travel within the next 30 days. (American) See all details »
$530 RT
Oakland, CA (OAK) Lowest fare found for travel within the next 30 days. (American) See all details »
$395 RT
Oklahoma City, OK (OKC) Lowest fare found for travel within the next 30 days. (Delta, US Airways) See all details »
$289 RT
Ontario, CA (ONT) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$367 RT
Orlando, FL (MCO) Lowest fare found for travel within the next 30 days. (American, US Airways) See all details »
$346 RT
Philadelphia, PA (PHL) Lowest fare found for travel within the next 30 days. (United) See all details »
$326 RT
Phoenix, AZ (PHX) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$358 RT
Pittsburgh, PA (PIT) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$429 RT
Portland, OR (PDX) Lowest fare found for travel within the next 30 days. (United) See all details »
$378 RT
Raleigh, NC (RDU) Lowest fare found for travel within the next 30 days. (American) See all details »
$326 RT
Richmond, VA (RIC) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$498 RT
Sacramento, CA (SMF) Lowest fare found for travel within the next 30 days. (American) See all details »
$319 RT
Salt Lake City, UT (SLC) Lowest fare found for travel within the next 30 days. (American) See all details »
$378 RT
San Antonio, TX (SAT) Lowest fare found for travel within the next 30 days. (United, Delta, US Airways, American) See all details »
$341 RT
San Diego, CA (SAN) Lowest fare found for travel within the next 30 days. (United, American) See all details »
$445 RT
San Francisco, CA (SFO) Lowest fare found for travel within the next 30 days. (American) See all details »
$452 RT
San Jose, CA (SJC) Lowest fare found for travel within the next 30 days. (American) See all details »
$387 RT
Seattle, WA (SEA) Lowest fare found for travel within the next 30 days. (United) See all details »
$477 RT
Spokane, WA (GEG) Lowest fare found for travel within the next 30 days. (US Airways, American) See all details »
$316 RT
St. Louis, MO (STL) Lowest fare found for travel within the next 30 days. (United, Delta, US Airways, American) See all details »
$382 RT
Tampa, FL (TPA) Lowest fare found for travel within the next 30 days. (US Airways) See all details »
$378 RT
Tucson, AZ (TUS) Lowest fare found for travel within the next 30 days. (United, US Airways, American) See all details »
$234 RT
Washington, D.C. (DCA) Lowest fare found for travel within the next 30 days. (United) See all details »
$249 RT
Washington, D.C. (IAD) Lowest fare found for travel within the next 30 days. (Delta) See all details »
$354 RT
West Palm Beach, FL (PBI) Lowest fare found for travel within the next 30 days. (Delta, American) See all details »
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