While fares to London and much of Western Europe remain high, Rome is sure looking reasonable, even from the West Coast.
We recently spotted fares from Los Angeles to Rome for $767 round-trip, on Aeroflot, for travel in fall/winter. And from Chicago, fares to Rome are steady at $676 round-trip, including all taxes on Turkish Airways, beginning in November. Plenty of other dates for fall/winter.
You'll find a complete round-up of fares to Rome FCO here.